Wednesday, October 15, 2008

Have DILT ?.........

[drug-induced liver toxicity}

Wanna know a fantastic website to check out if you have been diagnosed with hepatotoxicity? GREAT!! U.S. Food and Drug Administration has an up-to-date, informative page explaining the definition as well as having resources to click on for further information reguarding involved research, networking, etc. Meetings are held for more knowledge of hepatotoxicity and this site has listed them all from 2001-2008 (EXCEPT 2002). INTERESTED?? Go check out the site www.fda.gov/cder/livertox/default.htm!
We will wait :)

OK :) now another helpful site is Drug-Induced Liver InjuryNetwork (DILIN)
http://dilin.dcri.duke.edu/
What makes this site interesting? Good, I am glad you asked! Research is the answer... DILIN is in the process of two studies. If your goal is networking to find out others experiencing similar situations check out Retrospective Study on their site. This particular experiement lists medications and names of diagnosed people. The other study, Prospective Study, has volunteers recently experiencing an adverse liver reaction and taking medication or herbs being followed to understand the why and how. And if that is not enough, breaking news about comparable topics are posted and also, clinical sites and locations too.

WANNA SECOND OPINION??
check out this upcoming workshop Dec 2008 http://www3.niddk.nih.gov/fund/other/diliworkshop2008/

Another organization:
AMERICAN LIVER FOUNDATION (ALF) http://www.liverfoundation.org/
1-888-4HEP-USA (443-4872) or 1-800-GO-LIVER(465-4837)



Sunday, October 12, 2008

Antibiotics induced Hepatotoxicity?




Can intake of too much antibiotics cause liver damage? Absolutely!!!. Telithromycin, an antibiotic class of the ketolide is normally used for treating certain respiratory infection in adults caused by streptococcus pneumoniae and Haemophilus influenzae that includes bronchitis and pneumonia. It was first approved by FDA on April 2004 but by January 2006, researchers were able to report severe cases of liver problems associated with ketek, including death. Due to this, FDA immediately issued a public health advisory and warned against its serious risk. A series of case study was conducted and was observed that patients, who were experiencing discoloring of their eyes and skin or appeared yellowish and had blurred vision we showing early signs and symptoms of liver damage. Telithromycin should only be used for infections caused by a susceptible microorganism. Because it is not effective against any sort of viral infection, consuming these would further expose patient with higher risk of side-effects without any benefits. The patients who were studied eventually reported to develop jaundice and abnormal liver function. Sever hepatitis and hepatocellular damage was also noticed in patience taking this antibiotics.